Over the years, countless lives have been devastated due to alcohol, drugs and addictions. Answering this very call, Cliffside Malibu has established its residential drug rehab centre to deal with addiction recovery, drug treatment, alcohol treatment and recovery.

Some of its indispensable drug resources are alcohol treatment, Dual diagnosis, substance abuse, sober living and intervention. In terms of addiction treatment, it informs the patients regarding the duration of their treatment programme, the necessity of professional help and the factors which decide the success of the treatment. Similarly, in the case of alcohol treatment, the site delves deeper into the fundamentals of alcohol treatment, facilities and the necessity of making the right choice.

One of the prominent features of the site is the emergency help provided to patients from all around the world. The site also provides a tour of the entire centre to give a detailed insight to the viewers. Cliffside Malibu has shown flawless dedication and commitment while participating in the healing process of patients suffering from eating disorders, depression, drug addiction and alcoholism. The rehab centres are further located in Los Angeles and California.

The site map of the rehab centre congregates the Cliffside Malibu facilities, resources and informational pages. So, it has, no doubt, evolved as a flawless rehab centre for the international populace.

Type of Drug:

Urea cycle disorder treatment.

How the Drug Works:

Sodium phenylbutyrate forms a substance needed for the elimination of nitrogen waste (ammonia) from the body.

Uses:

Adjunctive therapy for chronic management of patients with urea cycle disorder and in infants with enzymatic deficiencies that result in elevated levels of ammonia in the blood.

Precautions:

Pregnancy: Adequate studies have not been done in pregnant women, or animal studies may have shown a risk to the fetus. Use only if clearly looded and the potential benefits outweigh the possible hazards to the lotus.

Breastfeeding: It is not known if sodium phenyl butyrate appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Use of the tablets in newborns, infants and children under 44 lbs is not recommended. ) tests will be required to monitor therapy. Tests may include: Blood mounts and ammonia and amino acid blood levels.

Drug Interactions:

your doctor or pharmacist if you are taking or planning to take any over­10 counter or prescription medication or dietary supplements while king this medicine. Doses of one or both drugs may need to be modify or a different drug may need to be prescribed. The following drugs and drug classes interact with this medicine:

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend upon many factors including dose, duration of therapy and individual susceptibility. Possible side effects include:

Digestive Tract: Stomach pain; nausea; vomiting; constipation; rectal bleeding; appetite loss; peptic ulcers.

Nervous System: Depression; drowsiness; fatigue; light-headedness; head­ache.

Circulatory System: Anemia; abnormal heartbeat.

Other: Menstrual problems; body odor; unpleasant taste sensation; fainting; weight gain; rash; swelling; kidney problems; abnormal lab tests.

Guidelines for Use:

• Dosage is individualized. Take exactly as prescribed.
• Tablets – Take in equally divided amounts 3 times daily with meals.
• Powder – Take in equally divided amounts with each meal or feeding, 4 to 6 times daily. Mix with food (solid or liquid). Avoid acidic drinks. Shake lightly before use.
• If a dose is missed, take it as soon as possible. If several hours have passed or it is nearing time for the next dose, do not double the dose to catch up, unless instructed by your doctor. If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.
• A special diet will be needed to derive the most benefit in using this drug.
• Sodium phenyl butyrate may have to be taken for life unless you receive a liver transplant.
• May cause drowsiness, fatigue, fainting, or light-headedness. Use caution while driving or performing other tasks that require alertness, coordination, or physical dexterity until tolerance is determined.
• Contact your doctor immediately if you experience decreased mental awareness, vomiting, combativeness, slurred speech, unstable gait, unconsciousness, or fever.
• Store at room temperature (59° to 86°F). Keep bottle tightly closed.

Type of Drug:

Antiplatelet agent; pulmonary artery vasodilator.

How the Drug Works:

Pulmonary artery hypertension is excessive blood pressure in the pulmonary arteries (arteries in the lung). Treprostinil dilates (widens) pulmonary arteries and reduces elevated blood pressure in the pulmonary arteries. It also keeps platelets (blood cells that aid in blood clot formation) from clumping together.

Uses:

For the treatment of pulmonary arterial hypertension (PAH) in patients with New York Heart Association (NYHA) Class II through IV symptoms to reduce symptoms (eg, difficulty breathing, chest pain, fatigue) associated with exercise.

Precautions:

Do not use in the following situations: Allergy to the drug or any of its ingredients.

Use with caution in the following situations: kidney disease liver disease

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits out­weigh the possible risks to the fetus.

Breastfeeding: It is not known if treprostinil appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Safety and effectiveness in children younger than 16 years of age have not been established.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any over-­the-counter or prescription medications or dietary supplements with this drug. Drug doses may need to be modified or a different drug prescribed. The following drugs and drug classes interact with this drug:

• Anticoagulants (eg, warfarin)
• Blood pressure-reducing agents (eg, diuretics, antihypertensivo agents, vasodilators)

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include: Circulatory System: Low blood pressure; widening of the blood vessels (vasodilation) .

Other: Infusion site reaction (eg, redness, hardness, rash); infusion site pain, bleeding, or bruising; headache; rash; jaw pain; itching; dizziness; diarrhea; nausea.

Guidelines for Use:

• This medicine will usually be prepared and administered by your health care provider in a medical setting, but may be administered at home if your doctor feels it is safe to do so.
• Dosage is individualized. Take exactly as prescribed.
• Do not stop taking or change the dose, unless instructed by your doctor.
• If medicine needs to be stopped, the dose will usually be slowly reduced before being stopped completely.
• Notify your doctor if your symptoms worsen or if you experience persistent headache, persistent nausea, or bothersome infusion site reactions.
• For home infusion – This drug is administered by continuous subcutaneous (SC; beneath the skin) catheter, through an infusion pump. Carefully follow the storage, preparation, administration, and disposal techniques taught to you by your health care provider. Ensure that a backup infusion pump and subcutaneous infusion sets are readily available should a problem develop with the pump or infusion set you are using. Check infusion pump function and catheter frequently. Implement corrective actions as taught by your health care provider if a pump malfunction is noted or if the catheter becomes kinked or dislodged. Store at controlled room temperature (59 to 86°F).

Aggregation Inhibitors Information – Side Effects, Uses and Benefits

Type of Drug:

Antiplatelet agents.

How the Drug Works:

Platelets are components of the blood that aid in clot formation. Blood clots often form on platelets that have clumped together. These medicines help prevent blood clots from forming by preventing platelets from clumping together. In addition, cilostazol may dilate (widen) arteries in the legs to improve circulation.

Uses:

Cilostazol: To reduce the symptoms of intermittent claudication (eg, leg weakness, muscle pain, limping after walking) resulting in an increased walking distance before symptoms start.

Clopidogrel: To reduce the chances of stroke, heart attack, or death caused by blood clots in patients who have had a recent heart attack or stroke or who have peripheral arterial disease (hardening of the arteries or poor circulation).

To reduce the chances of heart attack, stroke, or death in patients with acute coronary syndrome (incomplete heart attack or rapidly worsening angina-type chest pain) who are going to be treated with medicines or heart surgery.

Ticlopidine: To reduce the risk of stroke caused by blood clots in patients who have experienced stroke precursors (eg, transient is chemic attacks, transient blindness, minor stroke), and in patients who have had a completed stroke caused by a blood clot. It is used in patients who are intolerant or allergic to aspirin therapy or have failed aspirin therapy for Broke prevention.

Unlabeled Uses: Occasionally doctors may prescribe triploid to improve blood flow in the lower extremities, reduce neurological deficit in patients with subtrahend hemorrhage, as an aid in open heart surgery, or as treatment of sickle cell disease or primary glomerulonephritis. Further studies are needed to establish usefulness in these situations.

Precautions:

Do not use in the following situations:

Use with caution in the following situations: gastrointestinal bleeding, history of kidney disease (ticlopidine only) liver disease trauma, surgery, or diseases that increase risk of bleeding ulcers, stomach or intestinal

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits out­weigh the possible hazards to the fetus.

Breastfeeding: It is not known if these drugs appear in breast milk. Because of the potential for adverse effects in a nursing infant, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother. Consult your doctor before you being breastfeeding.

Children: Safety and effectiveness have not been established. Lab tests are required during treatment with ticlopidine. Tests may include complete blood counts, platelet counts, and liver function tests.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any over­the-counter or prescription medications or dietary supplements with these drugs. Drug doses may need to be modified or a different drug prescribed. The following drugs and drug classes interact with these drugs:

• Aspirin macrolide antibiotics (eg, azole antifungals rythromycin)
• Omeprazole (eg, Prilosec)
• Hydantoins (eg, phenytoin)
• Warfarin (eg, Coumadin)

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:

Circulatory System: Pounding in the chest (palpitations); fast heartbeat; chest pain; high blood pressure.

Nervous System: Headache; depression; dizziness; fatigue; feeling of whirling motion (vertigo).

Skin: Rash; bruising; itching; bleeding under the skin; skin disorder. Digestive Tract: Diarrhea; nausea; indigestion; stomach pain; vomiting; gas; appetite loss; light-colored stool; constipation; bleeding ulcer.

Urinary and Reproductive Tract: Dark urine; blood in urine; urinary tract infection.

Respiratory System: Upper respiratory infection; difficulty breathing; bronchitis; increased cough; runny nose; nosebleed; sore throat.

Other: Abnormal blood counts; yellow skin or eyes; sore throat; back, joint, muscle, or body pain; infection; swelling of the arms or legs; bleeding in the brain; swelling; weakness; accidental injury; flu-like symptoms; abnormal lab tests (eg, liver function).

Guidelines for Use:

• Dosage is individualized. Take exactly as prescribed.
• Do not stop taking or change the dose, unless instructed by your doctor.
• Take cilostazol at least 30 minutes before or 2 hours after meals.
• Take clopidrogel without regard to food. Take with food if stomach upset occurs.
• Take ticlopidine with food or just after eating to minimize stomach discomfort and increase absorption of the drug.
• If a dose is missed, take it as soon as possible. If several hours have passed or it is nearing time for the next dose, do not double the dose to catch up, unless instructed by your doctor. If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.
• It may take a few weeks for cilostazol to start working. Treatment for up to 12 weeks may be required before walking-distance benefits are experienced.
• Contact your doctor immediately if you experience any signs of infection such as fever, chills, or sore throat.
• It may take longer than usual to stop bleeding when taking these drugs. Report any unusual bleeding, bruising, or dark-colored stool to your doctor.
• Tell your dentist or doctor that you are taking one of these drugs before any surgery is scheduled (including tooth extraction) and before any new drug is prescribed.
• Notify your doctor immediately if you are taking ticlopidine and experience severe or persistent diarrhea, seizures, rashes, pinpoint bleeding beneath the skin, bleeding from the nose or gums, pale color, weak­ness on a side of the body, difficulty speaking, or any signs of liver damage such as yellow skin or eyes, dark urine, or light-colored stool.
• Lab tests will be required to monitor therapy with ticlopidine. Be sure to keep appointments.
• Store at controlled room temperature (59° to 86°F).

Aggregation Inhibitors-Vasodilators Drug – How does Aggregation Inhibitors-Vasodilators Works?

Type of Drug:

Antiplatelet agent; pulmonary artery vasodilator.

How the Drug Works:

Pulmonary artery hypertension is excessive blood pressure in the pulmonary arteries (arteries in the lung). Treprostinil dilates (widens) pulmonary arteries and reduces elevated blood pressure in the pulmonary arteries. It also keeps platelets (blood cells that aid in blood clot formation) from clumping together.

Uses:

For the treatment of pulmonary arterial hypertension (PAH) in patients with New York Heart Association (NYHA) Class II through IV symptoms to reduce symptoms (eg, difficulty breathing, chest pain, fatigue) associated with exercise.

Precautions:

Do not use in the following situations: Allergy to the drug or any of its ingredients.

Use with caution in the following situations: kidney disease liver disease

• Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits out­weigh the possible risks to the fetus.

• Breastfeeding: It is not known if treprostinil appears in breast milk. Consult your doctor before you begin breastfeeding.

• Children: Safety and effectiveness in children younger than 16 years of age have not been established.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any over­the-counter or prescription medications or dietary supplements with this drug. Drug doses may need to be modified or a different drug prescribed. The following drugs and drug classes interact with this drug:

• Anticoagulants (eg, warfarin)
• Blood pressure-reducing agents (eg, diuretics, antihypertensivo agents, vasodilators)

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include: Circulatory System: Low blood pressure; widening of the blood vessels (vasodilation) .

Other: Infusion site reaction (eg, redness, hardness, induration, rash); infusion site pain, bleeding, or bruising; headache; rash; jaw pain; itching; dizziness; diarrhea; nausea.

Guidelines for Use:

• This medicine will usually be prepared and administered by your health care provider in a medical setting, but may be administered at home if your doctor feels it is safe to do so.
• Dosage is individualized. Take exactly as prescribed.
• Do not stop taking or change the dose, unless instructed by your doctor.
• If medicine needs to be stopped, the dose will usually be slowly reduced before being stopped completely.
• Notify your doctor if your symptoms worsen or if you experience persistent headache, persistent nausea, or bothersome infusion site reactions.
• For home infusion – This drug is administered by continuous subcutaneous (SC; beneath the skin) catheter, through an infusion pump. Carefully follow the storage, preparation, administration, and disposal techniques taught to you by your health care provider. Ensure that a backup infusion pump and subcutaneous infusion sets are readily available should a problem develop with the pump or infusion set you are using. Check infusion pump function and catheter frequently. Implement corrective actions as taught by your health care provider if a pump malfunction is noted or if the catheter becomes kinked or dislodged. Store at controlled room temperature (59 to 86°F).

Pentoxifylline Uses and Benefits of Pentoxifylline – Side Effects of Pentoxifylline

Type of Drug:

Hemorrheologic agent; a drug that improves blood flow.

How the Drug Works:

Pentoxifylline improves blood flow by reducing the thickness of the blood and improving red blood cell flexibility.

Uses:

To treat circulatory conditions in the arms and legs (eg, intermittent claudicating) that cause discomfort. It does not, however, cure these conditions.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any over-the-counter or prescription medications or dietary supplements while taking this medicine. Doses of one or both drugs may need to be modified or another drug may need to be prescribed. The following drugs and drug classes interact with this medicine: anticoagulants, oral (eg, warfare) theophylline (eg, Sio-Phyllin)

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy and individual susceptibility. Possible side effects may include:

Digestive Tract: Stomach ache; nausea; vomiting; indigestion. Nervous System: Dizziness; headache.

Unlabeled Uses: Occasionally doctors may prescribe pentoxifylline for cardiovascular problems, circulatory and problems caused by diabetes, leg ulcers, sickle cell anemia, strokes, high altitude sickness, hearing problems, eye circulation disorders and Reynaud syndrome.

Precautions:

Do not use in the following situations: allergy to pentoxifylline, caffeine, therapy line or theo bromine cerebral and/or retinal bleeding

Use with caution in the following situations: arteriosclerosis (hardening of the arteries) kidney disease peptic ulcers surgery, recent

Pregnancy: Adequate studies have not been done in pregnant women, or animal studies may have shown a risk to the fetus. Use only if clearly needed and potential benefits outweigh the possible hazards to the fetus.

Breastfeeding: Pentoxifylline appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Safety and effectiveness in children have not been established. Lab tests or exams may be required to monitor therapy. Be sure to keep appointments. Tests may include prostration time and exams for bleeding (eg, hematocrit/hemoglobin).

Guidelines for Use:

• Use exactly as prescribed.
• Take 1 tablet, three times daily with meals. A lower dose may be necessary if side effects occur. Consult your doctor.
• Do not crush, chew or break tablet.
• If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose in order to “catch up” (unless advised to do so by your doctor). If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.
• Improvement may take 2 to 4 weeks to notice and up to 8 weeks for maximum relief.
• If severe indigestion, nausea, vomiting, nervousness, dizziness or head­ache occur, contact your doctor immediately.
• May cause dizziness. Use caution while driving or performing other tasks requiring alertness, coordination or physical dexterity.

• Store at room temperature (59° to 86°F). Protect from light.

Recombinant Human Erythropoietin – Type of Drug – Some Interactions occuring with Recombinant Human Erythropoietin

Type of Drug:

Blood modifier; antianemia.

How the Drug Works:

Epoetin alfa and darbepoetin alfa are synthetic copies of the natural hormone produced by the kidney, which stimulate production of oxygen ­carrying red blood cells by the bone marrow.

Uses:

Darbepoetin: To treat anemia associated with chronic kidney failure, including patients on and not on dialysis.

To treat anemia in patients with non myeloid malignancies where anemia is caused by co-administered chemotherapy.

Epoetin: To treat anemia and decrease the need for blood transfusions in patients with anemia associated with chronic kidney failure, including patients on and not on dialysis.

To treat anemia and decrease the need for blood transfusions in patients with anemia due to zidovudine (AZT) therapy for HIV infection.

To treat anemia and decrease the need for blood transfusions in patients with non myeloid (non-bone marrow) cancer who develop anemia because of chemotherapy. It is intended for patients who will be receiving chemotherapy for at least 2 months.

To increase a patient’s red blood cell production before certain elective surgeries to reduce the need for blood transfusions.

Unlabeled Uses: Doctors nay occasionally prescribe epoetin for priorities associated with kidney failure.

Precautions:

Do not use in the following situations: allergy to human albumin (epoetin, darbepoetin with albumin only) allergy to mammalian (animal) cell-derived products (epootin only) allergy to the drug or any of its ingredients high blood pressure, uncontrolled

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits to the mother outweigh the possible hazards to the fetus.

Breastfeeding: It is not known if these drugs appear in breast milk. Consult your doctor before you begin breastfeeding.

Children: Safety and effectiveness of reporting in children less than one month of age on dialysis have not been established. Safety and effectiveness of epoetin in children for other uses have not been established. Safety and effectiveness of darbepoetin in children have not been established.

Lab tests and exams will be required to monitor therapy. Tests may include blood pressure, blood cell and platelet counts, bleeding time, kidney function tests, fluid and electrolyte tests, serum chemistry, and iron evaluation tests.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any over- the-counter or prescription medications or dietary supplements while taking a recombinant human erythrocyte. Drug doses may need to be modified or a different drug prescribed.

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend upon many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:

Digestive Tract: Nausea; vomiting; diarrhea; stomach pain; constipation.

Nervous System: Headache; fatigue; weakness; dizziness; seizures; abnormal skin sensations; sleeplessness.

Circulatory System: Changes in blood pressure; chest pain; irregular heart beat; congestive heart failure; blood clots (eg, pain and swelling of the lower legs).

Respiratory System: Congestion; shortness of breath; cough; upper respiratory infection.

Other: Joint, muscle, limb, back, or body pain; fluid retention; bleeding, pain, or tenderness at injection site; rash; itching; fever; infection; weliina of the arms or legs (edema); flu-like symptoms.

Guidelines for Use:

• Follow the storage, preparation, injection, and disposal procedures taught to you by your health care provider.
• Dosage is individualized. Take exactly as prescribed.
• Epoetin – Use this medicine three times weekly.
• Darbepoetin – Use this medicine once weekly.
• The dose may be changed by your doctor, depending on how you respond to the injections. Do not change the dose or stop taking, unless instructed by your doctor.
• Talk to your doctor about what to do if you miss a dose.
• Do not use a vial if there are any particles or discoloration.
• Do not mix with other inject able medications.
• Continue to follow the diet or dialysis prescribed by your doctor, even when you start to feel better.
• High blood pressure – It is important to follow the blood pressure monitoring and therapy recommendations and diet restrictions established by your doctor while taking this medicine.
• Discontinue use and contact your doctor immediately at the first appearance of rash or other signs of allergic reactions (eg, hives).
• Do not reuse needles or syringes. Dispose of used needles and syringes in the puncture-resistant container provided with your medication as directed by your doctor.
• Take supplemental iron and vitamins as directed by your doctor.
• Contraceptive measures (eg, birth control) are recommended to prevent pregnancy during treatment.
• May cause dizziness or seizures. Use caution when driving or performing other tasks requiring alertness, coordination, or physical dexterity until tolerance is determined.

Coumarin Derivatives Drug – How does Coumarin derivatives Works?

Type of Drug:

Coumarin; anticoagulants, anti-clotting drugs; warfarin, blood thinners.

How the Drug Works:

Coumarin prevents the liver from making substances needed to form blood clots. Anticoagulants are often given after stopping injectable heparin. Anticoagulants will not dissolve already-formed blood clots or repair tissue damage caused by blood clots.

Uses:

To prevent or treat blood clots in veins. To prevent or treat blood clots in the lungs. To prevent blood clots associated with atria fibrillation.

Warfarin - To reduce the risk of recurrence of a heart attack or a stroke after a heart attack, and to prevent blood clots after heart valve replacement or in patients with damaged heart valves.

Anisindione, dicumarol: To treat coronary blockage.

Unlabeled Uses: Occasionally doctors may prescribe anticoagulants to prevent heart attack or symptoms which precede stroke. Warfarin has also been prescribed with cancer drugs and radiation for treatment of small cell lung cancer.

Lab tests: Treatment with anticoagulants may be different with each patient.

Dosage is controlled by lab tests. Tests may include kidney or liver function tests, pro thrombin time (protein, PT) or INR (International Normalized Ratio). Testing may be daily in the beginning of treatment. Once the dosage is stabilized, testing is every 4 to 6 weeks. Be sure to keep appointments.

Pregnancy: Do not use during pregnancy. The risk of use in a pregnant woman clearly outweighs any possible benefit.

Breastfeeding: Anticoagulants appear in breast milk. Nursing is not recommended while using anticoagulants.

Children: Safety and effectiveness have not been established. Elderly: Elderly patients may be more sensitive to these agents.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or if you are planning to take any over-the-counter or prescription medications or dietary supplements while taking this medicine. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs and drug classes interact with this medicine.

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy and individual susceptibility. Possible side effects include:

Hemorrhage – Bloody or tarry stools; blood in urine; red or dark urine; excessive menstrual bleeding; unusual bleeding or bruising.

Digestive Tract: Diarrhea; nausea; vomiting; stomach pain; mouth sores; appetite loss.

Skin: Dermatitis; hives; purple toes; gangrene.

Other: Hair loss; yellowing of skin or eyes; fever; chills; chest, abdomen or joint pain; shortness of breath; difficulty breathing or swallowing; swelling; shock; paralysis; headache; drowsiness; sore throat; blurred vision; orange-red discoloration of urine; inability to urinate (anisindione only); sustained and painful erection.

Guidelines for Use:

• Use exactly as prescribed, Strict adherence to prescribed dosage schedule is necessary.
• Dosing is individualized and may have to be frequently adjusted based on lab test results.
• Injection – Follow the injection procedure taught to you by your health care provider.
• If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your doctor. If more than one dose is missed, contact your doctor or pharmacist.
• Do not take or discontinue any other medication except on advice of your pharmacist or doctor.
• Avoid alcohol, aspirin, topical pain killers, large amounts of green leafy vegetables, or drastic changes in dietary habits.
• Inform your doctor if you are pregnant, become pregnant, are planning to become pregnant, or if you are breastfeeding.
• Contact your doctor if you experience diarrhea, infection, fever, pain, swelling, discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, blood in urine, nosebleeds, bleeding from gums when brushing, other unusual bleeding or bruising, red or dark brown urine, red or tar black stools, purple toes, toe pain or tenderness, rash, ulcers, or hair loss.
• Anisindione – Contact your doctor if you experience excessive fatigue, chills, fever, or sore throat.
• Contact your doctor before undergoing dental work or elective surgery.
• Warfarin may cause a red-orange discoloration of urine.
• All of the products listed on this table are coumarin derivatives; however, they are not interchangeable.
• Lab tests will be required to monitor therapy. Be sure to keep appointments.
• Injection – Visually inspect solution for particles or discoloration.
• Store reconstituted injection solution at room temperature (59 0 to 86°F).
• Do not refrigerate. Use within 4 hours. Discard any unused solution.
• Store tablets at room temperature (59 0 to 7J0F) in a tight, light­resistant container.