Some Tricyclic Antidepressants and Their Recommended Dosage

Mipramine HCI:

  • Usual initial adult dose for outpatients is 75 mg/day increased to 150 mg/day. Doses over 200 mg/day are not recommended. Maintenance dose is 50 to 150 mg/day.
  • For hospitalized patients, usual initial adult dosage is 100 mg/day in divided doses gradually increased to 200 mg/day as required. If no response occurs after 2 weeks, increase dose to 250 to 300 mg/day.
  • For adolescents and elderly patients, usual initial dose is 30 to 40 mg/day, not to exceed 100 mg/day.
  • Childhood bed wetting – An oral dosage of 25 mg/day given 1 hour before bedtime should be tried in children 6 years of age and older.
  • If satisfactory response does not occur within 1 week, increase the dose to 50 mg nightly in children younger than 12 years of age; children older than 12 may receive up to 75 mg nightly.
  • Doses larger than 75 mg do not work better and tend to incense the side effects.

Imipramine HCI (cant.):

  • Consider instituting a drug-free period following an adequate therapeutic trial with a favorable response.
  • To reduce the tendency to relapse, taper dosage gradually rather than discontinue abruptly.

Imipramine pamaate:

  • Initiate adult dose for outpatients at 75 mg/day and increase to 150 mg/day, which is the dose level at which optimum response is usually obtained. If necessary, dose may be increased to 200 mg/day. Doses higher than 75 mg/day may also be administered on a once-a­day basis at bedtime after the optimum dosage and tolerance have been determined.
  • Maintenance dosage is usually 75 to 150 mg/day administered on a once-a-day basis, preferably at bedtime.


  • Usual adult dosage is 25 mg 3 to 4 times daily. As an alternative regimen, the total daily dose may be given once a day.
  • Doses above 150 mg/day per day are not recommended.
  • Usual dosage in elderly patients is 30 to 50 mg/day in divided doses.


  • Usual adult dosage is 15 to 40 mg/day divided into 3 or 4 doses. If necessary, dose may be increased to 60 mg/day. Make dose increases with the morning dose.
  • Doses above 60 mg/day are not recommended.
  • For elderly patients, the usual dosage is 5 mg 3 times a day initially and is increased gradually. The cardiovascular system must be monitored closely if the daily dose exceeds 20 mg.


  • Usual initial adult dosage for outpatients is 75 mg/day in divided doses. May be increased to 150 mg/day if needed.
  • Doses over 200 mg/day are not recommended.
  • Hospitalized patients may be given 100 mg/day initially in divided doses, increased gradually in a few days to 200 mg/day. If improvement does not occur in 2 to 3 weeks, the dose may be increased to the maxi­mum recommended dose of 250 to 300 mg/day.
  • Usual initial dose for adolescents and elderly patients is 50 mg/day, increasing in gradual increments up to 100 mg/day.

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