Desmopressin Acetate Guidelines of Usage

Type of Drug:Human antidiuretic hormone (ADH).

How the Drug Works:

A hormone which makes the kidneys reabsorb (retain) water and increases the concentration/activity of certain blood factors necessary for normal blood clotting.


DDA VP: As antidiuretic hormone replacement therapy in the management of central cranial diabetes insipidus and for temporary excessive urination and excessive thirst following head injury or surgery in the pituitary region. This will allow return to a more normal lifestyle with decreased urinary frequency and nighttime urination.

To treat nighttime bed-wetting (nasal solution only). May be used alone or in combination with behavioral conditioning or other non medicinal intervention.

To control bleeding in hemophilia A patients during and after surgery, and to stop spontaneous or trauma-induced bleeding in hemophilia A patients (injection only).

To control bleeding in patients with mild to moderate von Willebrand disease (Type I) during and after surgery, and to stop spontaneous or trauma-induced bleeding in patients with von Willebrand disease (injection only).

Stimate: To stop spontaneous or trauma-induced bleeding in patients with hemophilia A or mild to moderate von Willebrand disease (Type I).

Unlabeled Uses:

Nasal solution - To treat chronic autonomic failure (eg, nighttime bed­wetting, over-night weight loss and morning dizziness or lightheadedness when rising from a sitting or lying position).

Water intoxication: Very young and elderly patients should drink only enough fluids to satisfy thirst in order to decrease the potential occurrence of water intoxication (over-load) and salt depletion in the blood.

Long-term use: There have been reports of reduced responsiveness or duration of effect in patients using the drug for more than 6 months. Consult your doctor if such changes occur.


Pregnancy: Studies in pregnant women or in animals have been judged not to show a risk to the fetus. However, no drug should be used during pregnancy unless clearly needed.

Breastfeeding: It is not known if desmopressin acetate appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Infants and children need careful fluid intake restrictions to prevent possible salt depletion in the blood and water intoxication (over­load). Nasal solution has been used safely and is modestly effective for short-term use (4 to 8 weeks) in children 6 years of age and older for the treatment of nighttime bed-wetting. Do not use injection in children under 3 months of age or the nasal solution in children under 11 months of age in the treatment of hemophilia A or von Willebrand disease. Safety and effectiveness have not been established in children under 12 years of age (injection) or under 3 months of age (nasal solution) with diabetes insipid us. Decompressing tablets have been used safely in children 4 years of age and older for periods of up to 44 months.

Lab tests may be necessary to monitor therapy. Be sure to keep appointments.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or if you are planning to

take any over-the-counter or prescription medications or dietary supplements while taking this medicine. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs and drug classes interact with this medicine.

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy and individual susceptibility. Possible side effects include:

DDA VP nasal solutions - Headache; runny nose; nausea; stomach cramps; vaginal pain; high blood pressure; facial flushing; nosebleed; sore throat; cough; difficulty breathing.

DDA VP injection - Redness, swelling or burning at injection site; head­ache; runny nose; nausea; stomach cramps; vaginal pain; high blood pressure; facial flushing.

Stimate nasal solution - Sleepiness; dizziness; itchy or light-sensitive eyes; sleeplessness; chills; warm feeling; pain; chest pain; palpitations (pounding in the chest); fast heartbeat; indigestion; fluid retention; vomiting; agitation; genital inflammation; difficulty breathing.

Guidelines for Use:

  • Read and follow patient instructions carefully and use exactly as prescribed.
  • If a dose is missed, take or use it as soon as Possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose in order to “catch up” (unless advised to do so by your doctor). If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.
  • If bleeding is not controlled or worsens, contact your doctor.
  • Contact your doctor if headache, shortness of breath, heartburn, nausea, stomach cramps or vaginal pain OCcurs.
  • Nasal solutions - For nasal use only. Use one spray per nostril. If used before surgery, administer 2 hours before the scheduled procedure.
  • Stimate Spray pump must be primed before the first use. To prime the pump, press down 4 times. The pump will stay primed for 1 week if refrigerated. Repair the pump after 1 week if not used. Discard any solution remaining after 25 doses since the amount delivered thereafter may be less than the required dose. Do not transfer the remaining solution to another bottle.
  • Storage- Refrigerate nasal solutions and injection at 36° to 46°F. When travel­ling, closed nasal solution containers may be kept at room temperature (72°F) for up to 3 weeks. Store tablets at room temperature (59° to 86°F) protected from heat and light.

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